Description
Dapoxetine (Priligy) is a short-acting selective serotonin reuptake inhibitor (SSRI) specifically developed for treatment of premature ejaculation (PE). Unlike other SSRIs of the class (Fluoxetine, Sertraline, etc.), Dapoxetine isn’t taken chronically but on-demand 1-3 hours before sexual activity.
Per study reports Dapoxetine blocks the serotonin transporter (SERT). Higher synaptic serotonin concentrations raise the threshold for the ejaculation reflex at the central level - ejaculation latency measurably extends. In studies Dapoxetine showed extension of intravaginal ejaculation latency time by factor 2-3 vs placebo.
What distinguishes Dapoxetine from chronic SSRIs is the rapid pharmacokinetics: plasma peak after 60-90 min, half-life 1-2 hours. Action is therefore quickly there and quickly gone - no chronic SSRI pharmacology with typical side effects like anorgasmia or mood swings that can appear under long SSRI therapy.
Known effects in studies: nausea (most common side effect, dose-dependent), dizziness, headache, diarrhea. Due to serotonergic action, caution with combinations with other serotonin-active substances.
In recreational research practice Dapoxetine is often combined with PDE-5 inhibitors (Sildenafil, Tadalafil) to address both latency extension and erection quality - two independent mechanisms, well-studied combination.
You can order Dapoxetine as oral tablets in one bottle with 30mg per tablet.
This information is for research and educational purposes only. No medical recommendations.
Risks & Safety
Dapoxetine sits in the mid range of the risk scale. As a short-acting SSRI the compound bypasses the typical chronic SSRI pharmacology, but several accompanying effects are documented.
Documented in studies and the literature:
- Nausea: nausea is the most commonly documented side effect and dose-dependent.
- Dizziness: dizziness is a consistently documented accompanying effect, and alcohol amplifies the orthostatic hypotension.
- Headache and diarrhea: described in the studies as further accompanying effects.
- Serotonin syndrome risk: combination with other serotonergic substances such as SSRIs, MAO inhibitors, MDMA or tryptamines carries a documented risk.
Monitoring via bloodwork is recommended. This classification does not replace medical advice. Risk and responsibility for any actual use lie entirely with the buyer.
Studies
- Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials - Lancet 2006, Pryor et al: Integrated analysis of two phase III RCTs, documents extended ejaculation latency under 30mg and 60mg.
- Dapoxetine for the Treatment of Premature Ejaculation: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial in 22 Countries - European Urology 2009, Buvat et al: International phase III approval study across 22 countries.
- Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for ‘on-demand’ treatment of premature ejaculation - BJU International 2006, Andersson et al: Review of the rapid pharmacokinetics enabling the on-demand profile.
