NAD+ Inject

NAD+ (Nicotinamide Adenine Dinucleotide) is not a peptide but a coenzyme - a cofactor needed in every single cell of your body. It sits in the mitochondrial respiratory chain, drives ATP production and fuels sirtuins and PARP enzymes for DNA repair and anti-aging pathways.

With age the NAD+ level in plasma drops dramatically - often halving by the mid-60s. Injection bypasses the full GI breakdown that makes oral NAD+ precursors so inefficient.

NAD+ is the central currency of cellular energy. Three main pathways use it:

• Mitochondria: electron transport in the respiratory chain, ATP production.
• Sirtuins (SIRT1-7): longevity enzymes that need NAD+ as cosubstrate.
• PARP enzymes: DNA repair after strand breaks, also NAD+ dependent.

If the NAD+ pool drops, all three pathways suffer simultaneously. Substitution aims to stabilize the level.

Three application routes in research:

• Subcutaneous: thin insulin needle in the abdomen, 1x daily. Practical for self-use.
• Intramuscular: in the upper arm, 1x daily. Slightly higher bioavailability than SC.
• Intravenous: clinical setting, often infused over 1-3 hours, 500-1000mg per session.

SC and IM can sting - the sensation fades within seconds.

NAD+ research is the absolute longevity mega-field of the last 10 years:

• Yoshino et al. 2018: NAD+ precursors improve mitochondrial function in aging.
• Mills et al. 2016: long-term NAD+ restoration extends healthy lifespan in mouse model.

Human data on direct NAD+ injection is smaller than on precursors like NMN and NR. But the mechanism picture is consistent.

• Burning at the injection site - normal, fades quickly.
• Too-rapid dosing up: mild nausea or hot feeling.
• Skin redness at the site for several hours.

Store vial dark and cool, ideally in the fridge. NAD+ is light-sensitive, keep original packaging closed.