What is P21-Adamantane?
P21-Adamantane is the adamantane-stabilized variant of the neurogenic peptide P21 (P021), which you also find individually in the lexicon. The attached adamantane makes the molecule more lipophilic and more resistant to breakdown, which extends the duration.
Up front: purely preclinical, no human data.
How it works
Like P21 it is derived from an active section of the nerve growth factor CNTF and is meant to promote the formation of new nerve cells and memory, among other things via raising BDNF. The adamantyl group is a pharmacological modification for more stability.
Details on the mechanism are in the P21 entry.
What you need
- The P21-Adamantane vial (lyophilized powder).
- Bacteriostatic water, U-100 insulin syringes, alcohol swabs.
Reconstitution
Use the calculator above. A 10mg vial with 2ml water gives 5mg per ml. Just add the water to the vial and let it dissolve.
Dosing
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Injection
Subcutaneous into the subcutaneous fat. Disinfect the site, pinch a skin fold, rotate sites.
What the research shows
The basis is the same as P21 (Kazim, 2014): oral P021 favorably influenced disease progression in an Alzheimer's mouse model. The adamantyl modification targets longer duration. There are no standalone human studies on P21-Adamantane, it is clearly experimental.
Side effects
- Solid human data are missing.
- Local reactions at the injection site.
Storage
Before mixing the powder is robust, normal room temperature (around 20 to 25 degrees) is fine, ideally kept in the dark. After mixing, keep in the fridge (2 to 8 degrees), do not freeze. It stays good there for at least 8 to 10 weeks with barely any loss of potency, in practice considerably longer. Swirl or shake to mix, both are fine.