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Lexicon

Cognition

Selank + Semax Blend

The two best-known Russian nootropics in one vial: selank for calm, semax for focus.

1 min read 2 sources Calculator Updated May 2026
Class
Nootropic blend (selank + semax)
Use
Nasal or subcutaneous (in mg)
Contents
Selank (10mg) + semax (10mg)
Status
Clinical data (Russia)

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Equipment

Equipment you need

For reconstitution and injection you need a bit of basic gear. Here are solid, cheap options:

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What is the Selank + Semax Blend?

This blend unites the two best-known peptides from Russian nootropic research: selank (anxiolytic) and semax (focusing, BDNF-raising), 10mg each in a 20mg vial. You also find both individually in the lexicon. The idea: calm and clarity in one.

How it works

Selank acts calming and anxiolytic via the GABA system without strong drowsiness. Semax raises BDNF and promotes focus and mental clarity. Together they are meant to support a balanced, alert state.

The individual mechanisms are in the lexicon entries for selank (NA-Selank-Amidate) and semax (NA-Semax-Amidate).

Use (nasal or subcutaneous)

Like the individual peptides, classically nasal, alternatively subcutaneous.

  • Nasal: a few drops per nostril.
  • Subcutaneous: a small amount with the insulin syringe, use the calculator above.

Dosing

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What the research shows

Selank showed an anxiolytic effect comparable to a tranquilizer in a clinical study, without its sedation (Zozulya, 2008). Semax raises BDNF and TrkB (Dolotov, 2006). For the fixed combination there is no separate study, the benefit derives from the individual compounds. Most research comes from Russia.

Side effects

  • Generally well tolerated, occasionally mild irritation of the nasal mucosa (nasal).
  • Rarely headache, inner restlessness if taken too late (semax part).

Storage

Before mixing the powder is robust, normal room temperature (around 20 to 25 degrees) is fine, ideally kept in the dark. After mixing, keep in the fridge (2 to 8 degrees), do not freeze. It stays good there for at least 8 to 10 weeks with barely any loss of potency, in practice considerably longer. Swirl or shake to mix, both are fine.

Evidence

Sources

  1. 1 Selank: clinical study on generalized anxiety disorder (vs. medazepam). Zozulya et al., Zhurnal Nevrologii i Psikhiatrii, 2008
  2. 2 Semax regulates BDNF and TrkB in the hippocampus (mechanism, preclinical). Dolotov et al., Brain Research, 2006

Keep reading

More in the lexicon

In the shop

Selank + Semax Blend in the catalog

Sizes, prices and availability for research use. Straight from the lexicon to the product page.

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