What is Teriparatide?
Teriparatide is the active piece of the body's own parathyroid hormone (the first 34 amino acids, hence PTH 1-34). It is clinically approved for treating osteoporosis and one of the few agents that actively builds bone rather than just slowing breakdown.
How it works
The trick is in the timing: continuously elevated parathyroid hormone breaks down bone, while a once-daily short dose stimulates the bone-building cells (osteoblasts) more than the breaking-down ones. Net new bone forms, especially in the spine and hip.
What you need
- The teriparatide vial (lyophilized powder).
- Bacteriostatic water, U-100 insulin syringes, alcohol swabs.
Reconstitution
Use the calculator above. Teriparatide is dosed in mcg (in the calculator as a fraction of mg, 0.02mg is 20mcg). A 10mg vial with 2ml water gives 5mg per ml. Just add the water to the vial and let it dissolve.
Dosing
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Injection
Subcutaneous into the subcutaneous fat (abdomen or thigh). Disinfect the site, pinch a skin fold, rotate sites.
What the research shows
The approval study (Neer, NEJM 2001) showed a marked reduction of new vertebral fractures and an increase in bone density in postmenopausal women with osteoporosis. Teriparatide is thus a well-evidenced, clinically established agent with solid data.
Side effects
- Dizziness, leg cramps, nausea, especially at the start.
- Temporary rise in blood calcium.
- Local reactions at the injection site.
Storage
Delicate: keep refrigerated throughout (2 to 8 degrees), do not freeze and protect from light.