Ipamorelin

Ipamorelin is a short peptide that stimulates growth-hormone release by engaging the ghrelin receptor (unlike GHRH analogues such as CJC-1295, which act on the GHRH receptor). What is special: ipamorelin is considered very selective, it triggers a GH pulse without notably raising cortisol, prolactin or hunger.

It is used subcutaneously, dosed in micrograms, often several times a day. It ships as a freeze-dried powder you dissolve in bacteriostatic water.

Ipamorelin mimics ghrelin and triggers a short, strong GH pulse at the pituitary. Because it is selective, that pulse stays relatively clean, without the side effects of older GH secretagogues.

Especially common is the combination with a GHRH analogue like CJC-1295: one provides the GHRH signal, the other the ghrelin stimulus, together giving a stronger GH output than either alone.

For subcutaneous use you need:

• The Ipamorelin vial with the freeze-dried powder
• Bacteriostatic water to dissolve it
• U-100 insulin syringes
• Alcohol swabs for the vial cap and the skin
• A sealable sharps container for used needles

The powder is dissolved in bacteriostatic water. How much water you add sets the concentration, and with it how many units you draw for your dose on the insulin syringe.

Use the calculator above for this: pick your vial size and the water volume, and you see the concentration and units per dose.

When dissolving, just add the bac water, it does not matter if it hits the powder directly. Then swirl or shake until everything has dissolved, both are fine.

The injection is subcutaneous, into the fat layer under the skin, classically the abdomen. Many place a dose before sleep, because the natural GH pulse comes in deep sleep anyway.

• Clean the spot with an alcohol swab and let it dry
• Pinch up a small fold of skin
• Insert the needle at a 45 to 90 degree angle
• Inject slowly, wait a moment, then withdraw
• Put the needle straight into the sharps container

Rotate the site.

Ipamorelin is the compound with which the concept of a selective GH secretagogue was described. The discovery and pharmacology work showed that it triggers a GH pulse while barely raising cortisol and prolactin, which sets it apart from older GH-releasing peptides. The data base is mainly preclinical and early-clinical; ipamorelin is not an approved medicine.

The study with a link is in the source block below.

Ipamorelin is considered clean compared to older GH secretagogues. Mostly mild things are reported: a brief warmth or flush after dosing, occasionally head pressure, and at higher doses the GH-typical water retention. All dose-dependent.

• Often combined with CJC-1295 for a stronger GH output.
• Dosing before sleep uses the natural GH rhythm.
• Inject with some gap from large, carb-heavy meals.

The undissolved powder is robust, normal room temperature (around 20 to 25 degrees) is fine, ideally kept in the dark. The reconstituted solution goes into the fridge (2 to 8 degrees) and stays stable there for at least 8 to 10 weeks with barely any loss of potency, in practice considerably longer. The bacteriostatic water brings a preservative that keeps the dissolved form stable for longer.