What is Trestolone Acetate?
Trestolone Acetate (MENT) is a synthetic anabolic androgen derived from the 19-nortestosterone family. Originally developed as a candidate for reversible male contraception, it has a short half-life of approximately one day, requiring daily injections.
MENT binds with high affinity to the androgen receptor and exhibits both strong anabolic and androgenic effects. In research contexts, it has been investigated for muscle growth, fat loss, and endocrine changes.
This information is for research and educational purposes only. No medical advice.
How it works
Trestolone works primarily through androgen receptor (AR) activation, leading to increased protein biosynthesis, enhanced nitrogen retention, and stimulated erythropoietin production. Compared to testosterone, MENT exhibits approximately 10-fold higher anabolic potency.
- Strong androgenic signaling causes scalp and facial oiliness, possible acne
- Suppression of the hypothalamic-pituitary-gonadal (HPG) axis with suppressed endogenous testosterone production
- Aromatization to estradiol is possible, creating potential estrogenic side effects
- Relatively rapid clearance (approximately 1 day) requires daily injection
Application and dosing
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What the research shows
Clinical trials on male contraception showed that trestolone at doses of 100 mg/week produced significant suppression of sperm production. Side effects included breast tenderness, weight gain, and mood changes.
- Studies on body composition suggest strong muscle building, but the evidence base for side effects at higher doses is limited
- Both estrogenic and androgenic effects occurred at all doses, making a balance difficult to achieve
- Seroconversion (antibody formation against the oil) was reported in some cases
- Return to baseline fertility occurred after cessation, but with variable timeline (weeks to months)
Side effects
Trestolone exhibits strong androgenic and estrogenic side effects due to its potency and partial aromatization.
- Androgenic: Acne, alopecia (male pattern hair loss in genetically predisposed), facial/scalp oiliness, irritability
- Estrogenic: Gynecomastia (breast tissue growth), fluid retention, elevated blood pressure
- HPG axis suppression: Testosterone decline, testicular atrophy possible - post-cycle therapy typical
- Cardiovascular: Potential blood pressure elevation, lipid profile changes
- Hepatic: Minimal for oil form; liver enzyme elevations not typical
- Psychiatric: Mood swings, aggression (in rare cases)
Storage
Trestolone Acetate oil must be stored at room temperature, protected from light. A refrigerator is not required and may actually promote crystallization.
- Temperature: 15-25°C ideal
- Light: Store in dark (original vials or amber glass)
- Moisture: Keep dry
- Shelf life: At least 2-3 years stable with proper storage
- After opening: Needle punctures increase infection risk - use sterile technique