This information is for research and educational purposes only. No medical recommendations. Products are not approved for human use. For health questions, consult a doctor.

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Muscle & performance

Methyltrenbolone (Metribolone)

An extremely potent 17alpha-methylated trenbolone derivative with pronounced anabolic and androgenic properties.

2 min read 1 sources Titration Updated June 2026
Class
Anabolic Steroid (methylated trenbolone)
Use
Research compound; extreme potency
Half-life
Approximately 16-18 hours (daily or every-other-day)
Status
WADA banned; controlled substance

Getting started

Typical dosing (research context)

Values per day in mg. Methyltrenbolone: oil-based, daily or every-other-day injection; half-life approximately 16-18 hours.

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What is Methyltrenbolone?

Methyltrenbolone (Metribolone) is a synthetic anabolic steroid based on the trenbolone backbone with a 17alpha-methyl group. This structure makes it one of the most potent anabolic steroids available - at a concentration of only 5 mg/ml, it already represents significant dosing strength.

The methyl group enhances oral bioavailability, but the oil form is administered via intramuscular injection. The extreme potency at very low doses requires special care in dosing and monitoring.

This information is for research and educational purposes only. No medical advice.

How it works

Methyltrenbolone has an exceptionally high affinity for the androgen receptor (AR) and shows minimal aromatization to estrogen. Its potency is often described as having an androgenicity index of approximately 500-600% of testosterone baseline.

  • Extremely strong anabolic activity - rapid protein biosynthesis and nitrogen retention
  • Strong androgenic signaling without typical estrogenic side effects (no aromatization potential)
  • Intense HPG axis suppression - nearly complete inhibition of endogenous testosterone production
  • Vascular effects: Enhanced capillary dilation, initial vascularity prominence, then potentially problematic

Application and dosing

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What the research shows

Research on methyltrenbolone is limited, as it has not been studied in large clinical trials due to its potency and side effect profile. However, reports from user experience and in vitro data suggest:

  • Extreme muscle-building effects documented, often with weight gains of 10-15 lbs in 4-6 weeks in animal models
  • Cardiovascular strain was substantial in models - hypertension and LDL elevation prominent
  • Hepatotoxicity: Despite oil form, liver enzyme changes observed in some models
  • Fertility recovery difficult and may take months

Side effects

Methyltrenbolone carries a substantial side effect profile due to its extreme potency.

  • Cardiovascular: Blood pressure spikes, LDL cholesterol elevation, HDL reduction, possible left ventricular hypertrophy
  • Androgenic: Intense acne, aggressive alopecia, facial/scalp oiliness, extreme libido increase
  • HPG axis: Complete testosterone suppression typical - longer recovery required
  • Hepatic: Potential hepatotoxicity despite oil form
  • Renal: Potential creatinine elevation, especially under dehydration
  • Psychiatric: Increased irritability, aggression, potentially severe mood swings
  • Other: Headaches, sleep disturbances, appetite suppression

Storage

Methyltrenbolone oil must be stored at room temperature, protected from light. The oil solution is stable with correct handling.

  • Temperature: 15-25°C ideal
  • Light: Store in dark (original vials or amber glass)
  • Moisture: Keep dry
  • Shelf life: 2-3 years stable with proper storage
  • Note: Small injection volumes require precise measurement - syringe-swap technique may be helpful

Practice

PCT / after coming off

Anabolic substances suppress the body's own testosterone production in the research context. Anyone who comes off a cycle (rather than running it continuously) typically uses a post-cycle therapy (PCT) to restart the natural axis (HPTA).

The standard scheme in the research/literature context combines a SERM (tamoxifen and/or clomifene, alternatively enclomiphene) over roughly four weeks, optionally preceded by HCG to re-sensitise the testes before the SERM block. An aromatase inhibitor (anastrozole/exemestane) belongs more to on-cycle estrogen control than to the PCT itself.

Tip: order the PCT items together with the cycle so they are already on hand when you come off.

This information serves research and educational purposes only. Not medical advice.

Evidence

Sources

  1. 1 Androgenic Potency of Methylated Androgens. Steroids Journal

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Methyltrenbolone (Metribolone) in the catalog

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