This information is for research and educational purposes only. No medical recommendations. Products are not approved for human use. For health questions, consult a doctor.

Lexicon

Muscle & performance

Anadrol Oil (Oxymetholone)

An extremely potent C17-alpha-alkylated anabolic steroid with extreme anabolic effects, known for rapid mass gain.

2 min read 1 sources Titration Updated June 2026
Class
Anabolic Steroid (C17-alpha-alkylated, extremely potent)
Use
Research compound; mass gain studies
Half-life
Approximately 8-9 hours (oil depot prolongs effect)
Status
WADA banned; controlled substance

Getting started

Typical dosing (research context)

Values per day in mg. Anadrol oil: intramuscular, daily or every-other-day; half-life approximately 8-9 hours.

Members only

Dosing recommendations are visible to logged-in members only. Logging in is free.

Log in / sign up

What is Anadrol Oil?

Anadrol (oxymetholone) is one of the most potent anabolic steroids available. Originally developed to treat anemia and bone wasting, it has since been studied in muscle-building and weight gain research. The oil form allows faster and more potent effects than oral formulations.

Anadrol is extremely strong in anabolic activity, resulting in rapid weight gain (up to 1-2 lbs per day possible). Hepatotoxicity is substantial due to C17-alpha alkylation.

This information is for research and educational purposes only. No medical advice.

How it works

Anadrol works through androgen receptor activation, but also through non-classical mechanisms enabled by its structure. The anabolic:androgenic ratio is exceptional, often calculated as 320:45 - i.e., extremely anabolic with relatively lower androgenicity.

  • Extreme nitrogen retention - rapid protein biosynthesis
  • Strong erythropoietin production - red blood cell production increased
  • Low to moderate aromatization, but estrogenic effects still possible through aromatization
  • Intense HPG axis suppression
  • Water and sodium retention prominent - rapid weight gains partly water

Application and dosing

Members only

Dosing recommendations are visible to logged-in members only. Logging in is free.

Log in / sign up

What the research shows

Anadrol was well-studied for therapeutic purposes (anemia, bone wasting) but less so for muscle gain in healthy individuals. Available evidence shows:

  • Extreme weight gains: 10-15 lbs in 4 weeks documented, but much is water
  • Lean mass gains: Still significant, but difficult to separate from fluid retention
  • Hepatotoxicity: Liver values (particularly ALKP and bilirubin) often substantially elevated
  • Cardiovascular: Blood pressure increases prominent, LDL cholesterol increases strong
  • Hematologic: Red blood cell increases can lead to polycythemia (too many red cells)

Side effects

Anadrol has a severe side effect profile, especially with prolonged use.

  • Hepatic: Extremely hepatotoxic - liver function should be regularly monitored, cirrhosis is a real risk at high doses/prolonged duration
  • Cardiovascular: Blood pressure increases often extreme, LDL cholesterol increases strong, HDL reduction
  • Hematologic: Polycythemia risk (too many red cells - can lead to thrombosis), liver function changes
  • Estrogenic: Despite low aromatization potential, gynecomastia possible (fluid retention amplifies this)
  • Androgenic: Acne (often severe), alopecia, aggressive mood
  • HPG axis: Complete suppression typical
  • Gastrointestinal: Stomach upset, nausea, rarely abdominal pain

Storage

Anadrol oil must be stored at room temperature, protected from light.

  • Temperature: 15-25°C ideal
  • Light: Store in dark (original vials or amber glass)
  • Moisture: Keep dry
  • Shelf life: 2-3 years stable with proper storage
  • Note: Cool storage possible, but not in refrigerator - may cause crystallization

Practice

PCT / after coming off

Anabolic substances suppress the body's own testosterone production in the research context. Anyone who comes off a cycle (rather than running it continuously) typically uses a post-cycle therapy (PCT) to restart the natural axis (HPTA).

The standard scheme in the research/literature context combines a SERM (tamoxifen and/or clomifene, alternatively enclomiphene) over roughly four weeks, optionally preceded by HCG to re-sensitise the testes before the SERM block. An aromatase inhibitor (anastrozole/exemestane) belongs more to on-cycle estrogen control than to the PCT itself.

Tip: order the PCT items together with the cycle so they are already on hand when you come off.

This information serves research and educational purposes only. Not medical advice.

Evidence

Sources

  1. 1 Oxymetholone Treatment in Patients with Aplastic Anemia. New England Journal of Medicine

Keep reading

More in the lexicon

In the shop

Anadrol Oil (Oxymetholone) in the catalog

Sizes, prices and availability for research use. Straight from the lexicon to the product page.

View in shop